check with your dr First, but i found that after taking for a few weeks or so, i could decrease the dose by half and the benefit only decreased slightly (realizing i'd gone for hours w/o thinking of a cig). Taking only 1 pill a day, before bed, made a Huge difference in nausea. Moniter how you feel, tho, half dose may not work well for all, and i had to have full dose in my system for a couple of weeks before dropping. There's always a way to work with, work around, over, under, or through, if it's worth doing & you want it bad enough, & as long as you keep trying, it's only a matter of time before you find what works for you.