Hey don't pack it in.
I've been in the same boat as you. Up down, up down, with mostly being down for many years now. At this point, I've lost my wife, and my work has suffered. I've tried Zoloft, Prozac, SAM-e, and now I'm trying 5-htp. At this point, I would try anything if I thought it would help. But, the main thing is to keep going forward. If you have any info on non-prescription drug therapies, please pass it on. Thanks.