Hi Kerma. Welcome.
Being unemployed is the pits for anyone who wants to work. And it is discouraging to keep running into a wall. I invite you to take the free Depression Test (the link is at the left of the page) and take the printed results to a doctor if it indicates you have depression. I'm not a doctor, but I get the impression that if only you had a job, you would be fine?
From your post, I take it you haven't worked outside the home yet? Congrats on successfully raising 4 children and then graduating with a degree!
There are government job centers that offer free courses in getting work. They conduct mock interviews, help you with a resume presentation and give you hints, ideas and contacts. People are constantly reinventing themselves, adding other skills to their resume, and they could help you with that.
Sometimes all that's needed to be hired is a little help, some creativity and verifiable references. (for instance, working at a doughnut shop for a few months can get you a reference for efficiency, accuracy, punctuality, and people skills, and that comes in handy while you look for more serious work.) It lets a prospective employer know you are serious about wanting to work too.
A diversity of interests and skills can sometimes make you a lot more appealing to an employer. For instance, consider how volunteering can benefit you too. It can also get you references.
I don't know what branch of science you're in, but science jobs are advertised in specialized journals, local Internet sites, Company sites, as well as the local paper. Do you have a list of *all* the type of companies that hire people with your skills? For instance, when touring a large computer manufacturing company a couple of years ago, I was surprised to learn that among others, they and some other large companies had a biologist, some lab specialists, and a dietician, nurses and an auditory specialist on staff.
Although unscientifically researched on my part, I've too often observed that among equally qualified candidates, few male hirers were courageous enough to hire a woman who was older than they were. This has always been something I've noticed. I've hired lots of staff too, and many women have also made this comment to me. Networkin