Hi Starr, I just got back online this week from computer problems or I would have responded sooner. I was on Remeron for a while and it really helped me. I have major, major, anxiety and panic issues along with my depression and I was always on "red alert", expecting the worst to happen. It didn't help that I had a high-pressure job then. By the time I got help, that state of high alert had become so normal for me that getting more relaxed actually could bring on a panic attack because my body was so unused to being relaxed it interpreted relaxation as a threat. Remereron got me past that and enabled me to get used to feeling less hyper-aware. Everyone reacts a bit differently to meds, for me the Remeron was sedating and it made me feel a little groggy(which was what I needed then)if it makes you feel groggy I recommend having someone else do your driving. I was eventually able to switch to a less sedating antidepressant, but Remeron was very helpful when I needed it.