This is for Meg who has been on Lexapro and doesn't see any difference. I am no expert but I know that when I started using Lexapro, I started seeing a differece within 2 days. I'm sure everyone is different but then it might not be the right one for you. They tried me on Wellbutrin at first and that made me worse. My depression has not ever made me feel suicidal but when I am at my worst, I just can't feel joy-I feel very lonely,(Iam married to a wonderful husband who loves me, wonderful grown children and 7 grandchildren whom I adore), very tired, no ambition to go anywhere and lots of crying over everything and nothing. I have been dealing with this for over 2 years. Right now I am on Cymbalta for the past 2-3 months--I don't why and neither does my Dr. but the lexapro just stopped working for me but it was My magic "Make me normal pill" for over a year. I am doing OK on the Cymbalta but not great... Talk to your Dr. I find that keeping a journal about how I feel helps me --I don't write in every day, just when I feel like it. It is very hard to talk to anyone about how I am feeling because everyone thinks you can do more than you are doing for yourself so I don't talk about it to just anyone unless I know they have been through it or continue to. People who have never dealt with this just don't understand. Listen to your body and talk to your Dr. I do like this website--it helps to know there are other people who are feeling the same way as you --it makes it not so overwhelming sometimes. That is my biggest problem with Depression for me --things that came easy before do not anymore and I hate that. I am 51 years old and I have always been a very positive person, very uplifting to other people ---I feel like such a loser sometimes it is awful. Some times you just have to get through the hour, the day, the week and so on and do the best you can. Remember one thing which is very important, TRY TO MAKE YOURSELF COME FIRST. That is very hard for me but I am learning to be a bit more selfish than the old me. Take care everyone!!!