I've been on SSRIs for about five years now. I started off on Paxil, got really bad side effects, went on Celexa, liked it but had to change relatively quickly for insurance reasons, went on Zoloft (hated it-did nothing for me) and now I've been on prozac for almost three years. While Prozac has worked, I'm becoming more and more depressed. I heard that SSRIs stop working after a time; is this true? Also, since I haven't been really happy with any SSRI I've tried, do you think it would be worth it to try something like Effexor? Has anyone else been in a situation that the SSRIs make everthing better, but not ideal, and switched to something else they liked more? I'd love some stories! Thanks!