If this is true for SSRI, it is also true for a lot of other anti-depressant drugs, since most of them work by inhibiting or blocking the reuptake by auto-receptors on the presynapstic neuron, of some type of neurotransmitter. The brain, its functions and its specific workings is extensively researched, but it remains a great mystery. Many other factors, either inside your brain/ body or in the environment can contribute to memory loss as well. My personal view is that anti-depressant drugs do have a, often still unknown, effect on the working of neurotransmitters in the brain. Neurotransmitters are responsible for many, many processes that go on in there and work different inside every individual brain. But, please, lets stop beating ourselves up for needing drugs to feel better. If I had any other physical condition I needed drugs for, would I take them?? You bet I would, so why not for depression. I think that is because depression is still a disease we feel ashamed of, we should not feel like that, we should feel happy and jolly all the time, we should be great success stories every single minute of the day and we should be able to fall asleep if we want to. Feeling bad is soooo unaccepted in our society. Anyway, I think taking drugs is never a good thing for your body. Read the side effects on any drugs (even the over the counter ones) and be shocked what can happen. I am not an advocate for taking drugs. You feel bad, pop a pill and you feel better. It does not work like that and many of you out there know that if anything finding the drug that might work for you is hard. Since drugs work on the neurotransmitters in the brain.....here are some things that do as well. Excercise, will raise the level of endorphines in your brain. The feel good neurotransmitter. Also, eating wholesome food to nourish you body will nourish your brain and all the cells in it to work at their best level. Sleep, the first few hours will release the growth hormone. Since I am doing these things I am feeling a lot better. I am not taking drugs anymore, but I have for a long time. I needed them to even start to think about excercising, eating well, keeping a regular schedule. I do not know, nor want to think about where I would be now if that option had not been available to me at