kendy, thanks for the reply. Last night I took only 12.5mg, seemed to help. I also didn't take my Singulair, rather I took it this morning. I take that for rhinitis, not asthma, so timing isn't important. I do feel much better today. I think that I will try the 12.5mg for a week or two and up to 25mg, if needed. I read that some people are slow metabolizers, and I think I must be one. the 25mg that I took the other night wouldn't even phase most people at all. I did read, though, that SSRI's are CYP450 3A4 inhibitors, and Singulair is metabolized by 3A4...interesting, eh? Also, both drugs are highly bound to serum proteins, and an overload means that something won't be bound...essentially an overdose due to the high conc. of free drug in your body. Thanks for the reply and good luck with your continued treatment!! Have a great afternoon,
Finneycat
