It can take time to find medications that work well for you. Each individual is different so it is important to work closely with a doctor and to not give up.
So I know this is a depression forum and I have bipolar 2, so my meds may be a little different than most of you guys. Right now I am on 100mg of lamictal, 30mg litium oratate, 50mg zoloft, and 300mg of wellbutrin. Honestly this combo is working really good for me right now and the only side effect I have is from lamictal and it is just super minor EPS in my hands. It took me two years to find this combo and I am really glad I did!